dtgreene: I remember it being possible to get tons of Master Balls just by seeing Missingno. with Master Balls as the 6th item in your inventory. Also works for other items, like Rare Candies, TMs, and Nuggets.
W1ldc44t: Yeah, my subsequent playthroughs have employed many new tricks that I was not aware of in the year 1999.
There's also the mechanics of the legendary "8F" item. In Red and Blue, this item can do *anything*; you just need to have your inventory spell out the machine language instructions to do what you want.
Worth noting that:
* The item's name "8F" is not a hex code; it means "8th floor".
* Actually obtaining this item requires other glitches, most notably item underflow (which also makes it possible to warp to the Hall of Fame room).
* Of course, you can't literally do anything this way; you can't, for example, do anything that could not be coded into a ROM hack of the game. But still, there's a lot you can do, including catching Mew and replacing the game with Pong.