I liked both Letho's and Iorweth's voices.
Letho sounded as if he was so experienced that he didn't care about anything anymore. I think his voice fitted his character.
Actually, I disliked the voices of the side characters (almost all of them, to be honest). In The Witcher 1 they were perfect, but in the Witcher 2 it was liek they hired the Dragon Age and Mass Effect's va and they sounded TERRIBLE.
Sasskia and Fillipa weren't very likeable as well. I want Thaler's voice actor to return, he was great I was very unhappy when I found out that they changed him (for Zoltan, that is). I almost stop playing because of that!