pimpmonkey2382.313: Nope those are the only two, neither connect plot wise, only they use the same setting from the pen and paper game. It might be wise to read through the pen and paper rulebook if only to get a grasp on the setting, how to build characters, etc. But other than that they're stand alone.
Also want to add the pen and paper game isn't required either, but will get your feet in the door about understanding the setting and mechanics a bit more.
Tallima: Thanks. I didn't even know these were a pnp rpg. I'll see what I can scrounge up on the net for rules. I know it was quite the adjustment going from dnd to the dark eye.
Yeah It's been around since I THINK the late 80's/early 90's somewhere in there. I have multiple versions of the PnP game, even a GURPS version of the game here beside me. But either way you can pick up and play either PC game with no problem.
Leroux: You don't really need any previous knowledge of the setting or the rules to enjoy the games. And you can play them independently of each other.
Redemption is mostly a dungeon crawler with mouse-controlled real-time combat (and a Pause key to issue orders that was later introduced with a patch, I think?), in which you click on opponents to kill them or use abilities. It can get a bit repetitive at times, but it's still worth playing. You play a fixed character and there aren't that many choices regarding the linear story, IIRC. A word of advice though: You can gain abilities by reading book, and your companions can, too, but if you want to be on the safe side, don't give these books to your companions. You can't know whether they'll be always by your side, and one battle is very difficult without a certain ability you'll find in one of these books.
Bloodlines is more action-oriented still, with WASD and mouse controls in close-up third person 3D view, combat is more like more like a brawler or shooter and depending on good player reactions in addition to character stats. You can create your own characters, male or female, with several vampire clans to choose from, and it may significantly impact the dialogue of the game (especially if you choose Malkavian). You also have a lot of freedom with regards to abilities, e.g. you can focus on stealth and diplomacy or technical knowledge and hacking instead of guns and swords, and you can deal with situations in many different ways. There are several different endings, too. I think the main criticism about the game though is that the balance gets off towards the ending and makes the last part hard for characters not skilled in fighting, so if you want to play it safe, invest enough points in fighting skills; you can still do a little sneaking and hacking in the side.
Knowing them before hand might be a bit of a smart move. Wandering around in public as a nosferatu would be a bad move. :P